In this study, purified poloxamer 407 was used at doses less than 10. In vitro evaluation of poloxamer in situ forming gels for bedaquiline. C corresponding to the formulation containing 18% poloxamer 407. Poloxamer 184 poloxamer 184 is a polyoxyethylene, polyoxypropylene block polymer. From products to protect buildings from termites to mosquito nets which effectively combat the spread of vectorborne diseases, we help our customers to keep their homes, food establishments, and businesses clean and pestfree.
It potentially has clinical utility in diverse diseases, such as acute myocardial infarction, acute limb ischemia, shock, acute stroke, heart failure, and sickle cell crisis. Brochures intermediates for special applications basf. For each ratio of ibuprofen and poloxamer 407, xylitol and lactose anhydrous were added separately at two levels 75 mg and 150 mg per unit dose containing 200 mg drug. It was suggested that hydrophobic sections of poloxamer 188 molecules are. It is a surfactant functioning both as cleansing and solubilizing agent. Safety assessment of poloxamers 101, 105, 108, 122, 123, 124, 181. Poloxamer 407mediated alterations in the activities of. Properties of poloxamer molecules and poloxamer micelles. Poloxamers are nonionic triblock copolymers composed of a central hydrophobic chain of. Pharmaceuticalgrade ingredients for the dermatology industry. Physical mixtures of ibuprofen and poloxamer 407 were prepared in ratios of 1. Basf corporation was supported on a polystyrene divinyl benzene solid matrix xad4. Poloxamers are also known by the trade names synperonics, pluronic, and kolliphor.
The word poloxamer was coined by the inventor, irving schmolka, who received the patent for these materials in 1973. P338 and p407 were bought from basf mannheim, germany and peg400 from clariant frankfurt am main, germany. Most of the common uses of poloxamer 407 are related to its surfactant properties. Electrodelivery of drugs into cancer cells in the presence of. Poloxamerbased thermoreversible gel for topical delivery. Narayan1 1technical service, basf corporation, roxbury, nj, 2pharmaceutical marketing, basf corporation, mount olive, nj. Technical information pluracare lf grades poloxamer. The effects of poloxamer 188, a triblock copolymer were studied on nanoparticle morphology, size, cancer cell uptake and cytotoxicity. Poloxamer 188 chemical information, properties, structures, articles, patents and more chemical data. With innovative products, global field support and industry leading technical expertise, basf mining solutions provides sustainable solutions which increase productivity, recovery and flexibility throughout the mining operations including leaching, solvent extraction, flotation, solidliquid separation and tailings management. About fagron fagrons strategy is focused on the optimization and innovation of pharmaceutical compounding. You will then be directed to your local website with complete product information for your local needs. Poloxamer 407 p407 and 188 p188 were obtained from basf co.
Based on its pkpd ratios, doxycycline hyclate doxh, a timedependant antibacterial, is ideally expected to achieve both sustained plasma drug concentrations at or slightly above the mic level for as long as possible between dosing intervals. We would like to show you a description here but the site wont allow us. Poloxamer 407mediated alterations in the activities of enzymes regulating lipid metabolism in rats. Basf to develop a high purity poloxamer for mast therapeutics. Pursuing this end, a poloxamer based matrix was used to produce a longacting injectable preparation doxhla and its serum concentrations vs. Pluracare l 64 is a copolymer of ethylene oxide and propylene oxide with an average molecular weight of 2,900. The present study was to understand the effect of poloxamer type on emodin solubility.
Poloxamer 407 is a triblock copolymer consisting of a central hydrophobic block of polypropylene glycol flanked by two hydrophilic blocks of polyethylene glycol peg. Kolliphor hs 15 is an exceptional solubilizer with attributes suited for parenteral and oral formulation of poorly soluble molecules. In vivo tmax of the im administered poloxamer in situ forming gels was about 6 h and a shortterm sustained drug. Effects of purified poloxamer 407 gel on vascular occlusion. The impurities of commercial grade poloxamer 188, as an example, include. Differential effects of commercialgrade and purified. Pdf research for new therapies to treat diseases like cancer, it is one of the focus of health sciences. An important characteristic of poloxamer solutions is their temperature dependent selfassembling and thermogelling. Basf corporation evaluation of lutrol f grades prill vs. Information material on polyurethane products and systems. Pdf poloxamer 407induced atherogenesis in the c57bl6 mouse.
Poloxamer complete drug information, side effects and. Basf poloxamers offer better solubilizing properties compared to hpmc, pvp. Topical formulations of poloxamer based thermoreversible gels are being modified to achieve improved compliance and bioavailability. Sep 26, 2017 the synthesis of selected polyoxyethylenepolyoxypropylene block copolymer poloxamer fatty acid monoesters is presented. Pge2 and poloxamer synperonic f108 enhance transduction of. Supelco in a highpressure stainless steel vessel and extracted with carbon dioxide and modifying cosolvents approximately 4 mole % at 6,000 psi and 40 c. In the range of concentrations studied, the t solgel of the binary waterpoloxamer formulations was inversely proportional to the poloxamer concentration, with the appropriate t solgel value 32. Basf also offers a range of smart solutions for pest problems in urban and rural areas. To study the properties of poloxamer molecules p85 and p188 and micelles containing these poloxamers in bulk water and also next to lipid bilayers, we performed coarsegrained molecular dynamics computer simulations. Assessment of transdermal penetration enhancement by topical. Pdf poloxamers, poloxamines and polymeric micelles. As a consequence, it is primarily used in screening of new chemical entities nces and also used as a vehicle in delivery of molecules encapsulated in micelles or microemulsions.
The effect of poloxamer 188 on nanoparticle morphology, size. Poloxamer 407 pluronic f127based polymeric micelles for. This section showcases our global product portfolio only. Organotin homogeneous catalyst sn bis2ethylhexanoate effectively catalyzed the esterification reaction of eopoeo block copolymer poloxamer with fatty acids. Information material on polyurethane systems and products basf. We previously reported on thermoreversible gel formulations based on poloxamer for the topical delivery of emodin. Poloxamer 407 p407 and poloxamer 188 p188 are the polymers frequently used for preparation of thermoreversible gels and enhancement of drug solubility, respectively. Poloxamerbased thermoreversible gel for topical delivery of. Pharmacokinetics of an injectable longacting formulation of. Basf engineering plastics offer decisive advantages over established metal structures in many areas.
Emodin is a component in a chinese herb, rheum officinale baill, traditionally used for diabetes and anticancer. Wasan 1, ramaswamy subramanian, mona kwong division of pharmaceutics and biopharmaceutics, faculty of pharmaceutical sciences, university of british columbia, vancouver, british columbia, canada. We first explored the use of pge2 and poloxamer synperonic f108 to enhance. Poloxamer 407 is a hydrophilic nonionic surfactant of the more general class of copolymers known as poloxamers.
To find technical product information, drawings, and details please use the country locator below and select the region and country of your choice. They make this highlyefficient intermediate, used in many types of applications, significantly easier and safer to handle. Kolliphor p 188 has been widely used as a thickening agent and gel binder. Poloxamer 407 p407 induces hyperlipidemia in the rat. Kolliphor p 188 is an poloxamer that enables and enhances a wide range of. Differential effects of commercialgrade and purified poloxamer.
Currently, excipientgrade poloxamer 188 nf, marketed by basf under the kolliphor p188 brand, is a polymer used in a variety of. Poloxamer 188, poloxamer 407 and carboxymethylcellulose were used for the preparation of thermosensitive in situ ocular gel. Dissolution rate enhancement and physicochemical characterization. Because the lengths of the polymer blocks can be customized, many different poloxamers exist that have slightly different properties. The range of applications for these intelligent plastic solutions extends far beyond automotive engineering and opens up significant development potential for the solar, construction and water industry. A nonionic surfactant that has general functionality of surfactant, emulsifier, solubilizer and stabilizer. Molecules free fulltext poloxamerbased thermoreversible. Poloxamer p407based ampbcontaining polymeric micelles administered by subcutaneous injections in murine models will turn into a semirigid gel, when in contact with the local tissue, creating a reservoir system and keeping the drug in the extracellular space, then allowing its action against the parasites in the local infection site. A supercritical fluid extraction process was used to prepare p188p.
Poloxamer 188 named also pluronik f68nf was from basf corporation usa, cisplatin. Assessment of transdermal penetration enhancement by topical pharmaceutical excipients using skin pampa method m. Used in toothpaste, whitening gels, mouthwash, sun and skin care applications. Possesses solubilizing, bodying and gelling properties. By using our services, you agree to our use of cookies. An important characteristic of poloxamer solutions is their temperature dependent selfassembling and thermo gelling. In the present study it is shown that poloxamer 188, added before or immediately after an electrical pulse used for electroporation, decreases the number of dead cells and at the same time does not reduce the number of reversible electropores through which small molecules cisplatin, bleomycin, or propidium iodide can passdiffuse. Abstractthis study investigates the potential of poloxamers as solid. Basf is the first company in the world to offer triphenylphosphine tpp in the form of pellets. You can find detailed information on our product range by looking up your industry or using our product finder. The high performance and safety of basf products is backed by comprehensive documentation so you know you can rely on us our flexible kolliphor solutions can be used for hotmelt and spraydrying processes basf poloxamers offer better solubilizing properties compared to hpmc, pvp and cyclodextrins.
Apr 11, 2014 poloxamer 188 p188 is a nonionic amphiphilic copolymer with hemorheologic, antithrombotic, antiinflammatory, and cytoprotective properties. Selective synthesis of polyoxyethylenepolyoxypropylene block. Article information, pdf download for safety assessment of poloxamers 101, 105, 108, 122. Its physicochemical and application relevant characteristics are attributed to.
Formulation development and optimization of ibuprofen. A comparative evaluation of poloxamer 407 and oxidized. Poloxamer 105 benzoate is an ester of poloxamer 105 and benzoic acid and poloxamer 182 dibenzoate is the diester of poloxamer 182 and benzoic acid gottschalck and mcewen 2004. This particular compound is also known by the basf trade name pluronic. Basf has a globally unique portfolio of chemical intermediates for the manufacture of outstandingly versatile polyurethane pur materials, including an extensive range of highperformance catalysts, polyols, additives and solvents.
Its poor solubility is one of the major challenges to pharmaceutical scientists. View mutual fund news, mutual fund market and mutual fund interest rates. An increased level of uptake of plgapoloxamer 188 nanoparticles in resistant human breast cancer cell line was demonstrated, resulting in a significantly higher level of cytotoxicity. Through science and innovation we provide our customers with products to meet the current and future needs of business and society. Emm 070801e00 january 2008 page 5 of 10 pluracare lf grades poloxamer rheological properties dilute aqueous solutions display newtonian flow, which is transformed into plastic flow with a pronounced change in flowability at concentrations above. Kolliphor hs 15 an enabler for parenteral and oral. Poloxamer 407 is a hydrophilic nonionic surfactant of the more general class of copolymers.
The ideal gel formulation would have a predictable dose. The reaction proceeded in high yield and high selectivity to monoesters. We have previously reported the feasibility of purified poloxamer 407 use for coronary vascular occlusion. To determine if poloxamer 407 poloxamer, pluronic f127. It was the purpose of this investigation to determine if chronic p407 administration would produce atherogenic arterial lesions in the. Physical and chemical properties as described by leaf 1967, many poloxamers dissolve in water and form gels when a concentrated aqueous solution is made. Download fulltext pdf download fulltext pdf carbopolincorporated thermoreversible gel for intranasal drug delivery article pdf available in molecules 203.
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